APOE genotype and Alzheimer disease risk across age, sex, and population ancestry

Resource type: Publication Publication
  • Authors
    Michael E. Belloy; Shea J. Andrews; Yann Le Guen; et al.
  • Type
    Original research
  • Journal
    JAMA Neurology
  • Publication Date
    2023
  • Abstract

    Importance: Apolipoprotein E (APOE)*2 and APOE*4 are, respectively, the strongest protective and risk-increasing, common genetic variants for late-onset Alzheimer disease (AD), making APOE status highly relevant toward clinical trial design and AD research broadly. The associations of APOE genotypes with AD are modulated by age, sex, race and ethnicity, and ancestry, but these associations remain unclear, particularly among racial and ethnic groups understudied in the AD and genetics research fields.

    Objective: To assess the stratified associations of APOE genotypes with AD risk across sex, age, race and ethnicity, and global population ancestry.

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