Hepatic steatosis and steatohepatitis: A functional meta-analysis of sex-based differences in transcriptomic studies

Resource type: Publication Publication
  • Authors
    Catala-Senent, Jose F; Hidalgo, Marta R; Berenguer, Marina; Parthasarathy, Gopanandan; Malhi, Harmeet; Malmierca-Merlo, Pablo; de la Iglesia-Vaya, Maria; Garcia-Garcia, Francisco
  • Type
    Original research
  • Journal
    Biology of Sex Differences
  • Publication Date
    2021
  • Abstract

    Previous studies have described sex-based differences in the epidemiological and clinical patterns of non-alcoholic fatty liver disease (NAFLD); however, we understand relatively little regarding the underlying molecular mechanisms. Herein, we present the first systematic review and meta-analysis of NAFLD transcriptomic studies to identify sex-based differences in the molecular mechanisms involved during the steatosis (NAFL) and steatohepatitis (NASH) stages of the disease.

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